The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
نویسندگان
چکیده
The biosynthetic gene clusters for the Hsp90 inhibitor geldanamycin (GDM, 1) have been cloned previously from three different Streptomyces strains, but the gene encoding the C-17 O-methyltransferase remains unknown. The cloning and sequencing of a new GDM biosynthetic gene cluster from Streptomyces autolyticus CGMCC 0516 was reported, identifying the gdmMT gene that encodes the missing C-17 O-methyltransferase for 1 biosynthesis.
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ورودعنوان ژورنال:
- Organic letters
دوره 13 14 شماره
صفحات -
تاریخ انتشار 2011